TRANSLATIONAL PHYSIOLOGY Malonyl-CoA decarboxylase inhibition suppresses fatty acid oxidation and reduces lactate production during demand-induced ischemia
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چکیده
William C. Stanley, Eric E. Morgan, Hazel Huang, Tracy A. McElfresh, Joseph P. Sterk, Isidore C. Okere, Margaret P. Chandler, Jiefei Cheng, Jason R. B. Dyck, and Gary D. Lopaschuk Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio; Chugai Pharma USA, San Diego, California; and Department of Pediatrics, University of Alberta and Metabolic Modulators Research Ltd., Edmonton, Alberta, Canada
منابع مشابه
Malonyl-CoA decarboxylase inhibition suppresses fatty acid oxidation and reduces lactate production during demand-induced ischemia.
The rate of cardiac fatty acid oxidation is regulated by the activity of carnitine palmitoyltransferase-I (CPT-I), which is inhibited by malonyl-CoA. We tested the hypothesis that the activity of the enzyme responsible for malonyl-CoA degradation, malonyl-CoA decarboxlyase (MCD), regulates myocardial malonyl-CoA content and the rate of fatty acid oxidation during demand-induced ischemia in vivo...
متن کاملFatty Acid Oxidation and Stimulating Glucose Oxidation Malonyl Coenzyme A Decarboxylase Inhibition Protects the Ischemic Heart by Inhibiting
Abnormally high rates of fatty acid oxidation and low rates of glucose oxidation are important contributors to the severity of ischemic heart disease. Malonyl coenzyme A (CoA) regulates fatty acid oxidation by inhibiting mitochondrial uptake of fatty acids. Malonyl CoA decarboxylase (MCD) is involved in the decarboxylation of malonyl CoA to acetyl CoA. Therefore, inhibition of MCD may decrease ...
متن کاملMalonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation.
Abnormally high rates of fatty acid oxidation and low rates of glucose oxidation are important contributors to the severity of ischemic heart disease. Malonyl coenzyme A (CoA) regulates fatty acid oxidation by inhibiting mitochondrial uptake of fatty acids. Malonyl CoA decarboxylase (MCD) is involved in the decarboxylation of malonyl CoA to acetyl CoA. Therefore, inhibition of MCD may decrease ...
متن کاملAMP-activated protein kinase regulation of fatty acid oxidation in the ischaemic heart.
The heart relies predominantly on a balance between fatty acids and glucose to generate its energy supply. There is an important interaction between the metabolic pathways of these two substrates in the heart. When circulating levels of fatty acids are high, fatty acid oxidation can dominate over glucose oxidation as a source of energy through feedback inhibition of the glucose oxidation pathwa...
متن کاملEffect of hyperglycemia and fatty acid oxidation inhibition during aerobic conditions and demand-induced ischemia.
Metabolic interventions improve performance during demand-induced ischemia by reducing myocardial lactate production and improving regional systolic function. We tested the hypotheses that 1) stimulation of glycolysis would increase lactate production and improve ventricular wall motion, and 2) the addition of fatty acid oxidation inhibition would reduce lactate production and further improve c...
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تاریخ انتشار 2005